Kohsuke Imai Selected Research

Hyper-IgM Immunodeficiency Syndrome (Hyper-IgM Syndrome)

10/2018	Clinical and molecular features of X-linked hyper IgM syndrome - An experience from North India.
1/2018	A Severe Anaphylactic Reaction Associated with IgM-Class Anti-Human IgG Antibodies in a Hyper-IgM Syndrome Type 2 Patient.
1/2018	Enhanced AKT Phosphorylation of Circulating B Cells in Patients With Activated PI3Kδ Syndrome.
3/2006	Female hyper IgM syndrome type 1 with a chromosomal translocation disrupting CD40LG.
6/2005	Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant hyper-IgM syndrome type 2.
2/2005	Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects.
10/2003	Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination.

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Kohsuke Imai Research Topics

Disease

18	Infections 01/2022 - 05/2008
9	Primary Immunodeficiency Diseases 01/2021 - 01/2009
7	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2022 - 12/2009
7	Common Variable Immunodeficiency 01/2021 - 05/2013
7	Wiskott-Aldrich Syndrome 09/2019 - 12/2003
7	Hyper-IgM Immunodeficiency Syndrome (Hyper-IgM Syndrome) 10/2018 - 10/2003
5	Agammaglobulinemia (Hypogammaglobulinemia) 01/2021 - 05/2014
5	Type 1 Hyper-IgM Immunodeficiency Syndrome 10/2018 - 07/2003
4	Graft vs Host Disease (Graft-Versus-Host Disease) 04/2022 - 05/2004
4	Ataxia Telangiectasia (Louis Bar Syndrome) 11/2019 - 08/2013
4	Thrombocytopenia 1 01/2015 - 12/2003
3	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2022 - 08/2012
3	Pneumonia (Pneumonitis) 10/2022 - 12/2021
3	Opportunistic Infections (Opportunistic Infection) 07/2022 - 03/2006
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 04/2022 - 01/2017
3	2 X-Linked Lymphoproliferative Syndrome 10/2021 - 06/2012
3	Neoplasms (Cancer) 01/2021 - 01/2018
3	Chronic Granulomatous Disease 01/2021 - 04/2017
3	Lymphopenia (Lymphocytopenia) 01/2021 - 01/2016
3	Autoimmune Diseases (Autoimmune Disease) 01/2020 - 10/2018
3	Eosinophilia 11/2019 - 08/2012
2	COVID-19 10/2022 - 03/2022
2	X-Linked Syndrome Enteropathy Polyendocrinopathy Immune Dysregulation 01/2022 - 01/2019
2	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 06/2021 - 01/2018
2	Splenomegaly 06/2021 - 01/2017
2	Job Syndrome (Hyper-IgE Syndrome) 01/2021 - 12/2014
2	Bone Marrow Failure Disorders 11/2020 - 01/2018
2	Virus Diseases (Viral Diseases) 01/2020 - 11/2018
2	Lymphadenopathy 11/2019 - 01/2016
2	Bronchiolitis Obliterans Syndrome 01/2019 - 01/2018
2	Respiratory Tract Infections (Respiratory Tract Infection) 01/2019 - 01/2018
2	Epstein-Barr Virus Infections 11/2018 - 01/2018
2	Leukemia 06/2018 - 05/2017
2	Respiratory Insufficiency (Respiratory Failure) 05/2018 - 08/2014
2	Disease Progression 01/2018 - 11/2008
2	Reticular dysgenesis 01/2018 - 01/2017
2	Hematologic Neoplasms (Hematological Malignancy) 05/2017 - 08/2013
2	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 01/2017 - 01/2011
2	Bruton type agammaglobulinemia 02/2016 - 03/2015
1	Cytomegalovirus Infections (Inclusion Disease) 10/2022
1	Atrophy 01/2022
1	Autoimmune Hepatitis 01/2022
1	Activated PI3K-delta Syndrome 01/2022
1	Arthralgia (Joint Pain) 01/2022
1	Cytopenia 01/2022
1	Autoimmune enteropathy 01/2022
1	Diarrhea 01/2022
1	Rare Diseases (Rare Disease) 01/2022
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 12/2021
1	Dysbiosis 10/2021
1	Kabuki syndrome 06/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021

Drug/Important Bio-Agent (IBA)

13	Immunoglobulins (Immunoglobulin)IBA 01/2022 - 02/2005
6	Immunoglobulin G (IgG)IBA 01/2018 - 03/2006
5	AutoantibodiesIBA 10/2022 - 01/2018
5	SteroidsIBA 04/2022 - 02/2013
5	Immunoglobulin M (IgM)IBA 01/2021 - 03/2006
5	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 11/2008
5	Busulfan (Busulfex)FDA Link 01/2021 - 05/2004
5	CD40 Ligand (CD40L)IBA 10/2018 - 07/2003
5	Proteins (Proteins, Gene)FDA Link 07/2017 - 12/2003
4	AntigensIBA 01/2022 - 08/2012
4	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2021 - 12/2009
4	Immunoglobulin E (IgE)IBA 11/2019 - 03/2006
4	Immunoglobulin A (IgA)IBA 01/2018 - 03/2006
3	Rituximab (Mabthera)FDA Link 01/2022 - 08/2013
3	X-Linked Inhibitor of Apoptosis ProteinIBA 10/2021 - 06/2012
3	DNA Ligase ATPIBA 11/2020 - 10/2015
3	Anti-Bacterial Agents (Antibiotics)IBA 11/2020 - 11/2018
3	STAT1 Transcription FactorIBA 08/2020 - 01/2018
3	Cytidine DeaminaseIBA 01/2018 - 07/2003
2	Interferon Type IIBA 10/2022 - 03/2022
2	EnzymesIBA 01/2022 - 04/2019
2	GlucocorticoidsIBA 01/2021 - 01/2019
2	Intravenous Immunoglobulins (IVIG)FDA Link 09/2019 - 01/2018
2	Cyclosporine (Ciclosporin)FDA LinkGeneric 09/2019 - 05/2004
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 05/2018 - 12/2016
2	Clofarabine (Clolar)FDA Link 05/2017 - 01/2016
2	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2016 - 07/2014
2	Immunoglobulin IsotypesIBA 03/2015 - 06/2005
2	Wiskott-Aldrich Syndrome ProteinIBA 02/2013 - 01/2004
2	Isoantigens (Alloantigen)IBA 06/2012 - 12/2010
2	A-Form DNA (A-DNA)IBA 02/2005 - 10/2003
2	Uracil-DNA GlycosidaseIBA 02/2005 - 10/2003
1	vedolizumabIBA 04/2022
1	Pharmaceutical PreparationsIBA 04/2022
1	Sirolimus (Rapamycin)FDA Link 01/2022
1	Abatacept (Orencia)FDA Link 01/2022
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2022
1	ruxolitinibIBA 12/2021
1	Inosine Triphosphate (ITP)IBA 06/2021
1	Melphalan (Alkeran)FDA LinkGeneric 01/2021

Therapy/Procedure

14	Therapeutics 10/2022 - 08/2012
14	Hematopoietic Stem Cell Transplantation 12/2021 - 05/2004
12	Cell Transplantation 07/2022 - 05/2017
9	Transplantation 04/2019 - 04/2015
5	Bone Marrow Transplantation (Transplantation, Bone Marrow) 07/2017 - 12/2010
4	Splenectomy 01/2022 - 04/2010
3	Stem Cell Transplantation 12/2021 - 02/2016
3	Drug Therapy (Chemotherapy) 06/2018 - 08/2013